Cytotoxic T lymphocytes (CTLs) secrete lytic proteins to destroy infected or cancerous cells. Using high-resolution 4D imaging, scientists at the University of Cambridge and National Institutes of Health have shown that CTLs approach target cells with actin-rich projections at the leading edge. Granules clustered around the centrosome move to the synapse between the 2 cells. As actin is removed from the area, granules secrete their deadly cargo of hydrolytic enzymes that destroy the target cell.
Ritter, A., Asano, Y., Stinchcombe, J., Dieckmann, N., Chen, B., Gawden-Bone, C., Engelenburg, S., Legant, W., Gao, L., Davidson, M., Betzig, E., Lippincott-Schwartz, J., & Griffiths, G. (2015). Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse. Immunity. 42(5): 864-875. Print. DOI: http://dx.doi.org/10.1016/j.immuni.2015.04.013
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