While the genetic cause(s) of autism are still mostly unknown, the most common single-gene cause is Fragile X Syndrome. Fragile X Syndrome accounts for 5% of autism cases and involves errors on the X chromosome that disrupt normal brain development.
Fragile X Syndrome prevents the production of FMRP, an important brain protein needed to activate the NOS1 gene. The NOS1 gene product is found throughout the developing human brain, especially in guiding the maturation of the speech, language, and decision-making centers.
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